David Raya keeps his place in goal for Arsenal ahead of Aaron Ramsdale following his clean sheet against Everton.
Kai Havertz replaces Fabio Vieira in midfield while Leandro Trossard comes in for the injured Gabriel Martinelli.
Gabriel Jesus is the third change for Arsenal as he starts up front instead of Eddie Nketiah.
Arsenal team news – Raya starts
Arsenal: Raya, White, Saliba, Gabriel, Zinchenko, Odegaard, Rice, Havertz, Saka, Gabriel Jesus, Trossard.
Subs: Ramsdale, Smith Rowe, Nketiah, Kiwior, Cedric, Tomiyasu, Jorginho, Vieira, Nelson, Elneny, Hein.
PSV team news
PSV: Benitez, Teze, Bella-Kotchap, Boscagli, Dest, Schouten, Veerman, Bakayoko, Saibari, Lang, de Jong.
Subs: Sambo, Ramalho, Tillman, Pepi, Drommel, Til, Waterman, Babadi, Lozano, van Aanholt, Vertessen.
