Arsenal manager, Mikel Arteta, makes two changes from his team that beat Brentford before the international break.
Martin Odegaard and Oleksandr Zinchenko returning from injury to replace Fabio Vieira and Kieran Tierney.
Thomas Partey is also deemed fit enough to start despite returning early from international duty with Ghana following a knock.
Gabriel Jesus will once again lead the line, flanked by Bukayo Saka and Gabriel Martinelli.
There are three changes for Spurs from the 6-2 win over Leicester, with Heung-min Son returning to the starting line-up following his 13-minute hat-trick.
He replaces Dejan Kulusevski, who misses out with an injury, while Cristian Romero comes into the defence in place of Davinson Sanchez, and Emerson Royal starts ahead of Ryan Sessegnon.
Harry Kane, who loves scoring against Arsenal, will lead the line.
