Erik ten Hag makes just one change from the 3-0 win over West Ham as Raphael Varane replaces Lisandro Martinez, who suffered a knee injury last weekend. A big blow for United losing their inspirational centre-back. Meanwhile, Luke Shaw makes his 250th Premier League appearance.
Aston Villa have made one change from the team who was beaten 3-1 by Chelsea in the FA Cup in midweek.
Youri Tielemans makes way for Jacob Ramsey in the attacking midfield position.
Pau Torres is still only fit enough for the bench, where January signing Morgan Rogers also sits.
Aston Villa team news
Team to play Man Utd: Martinez; Cash, Carlos, Lenglet, Moreno; Kamara, McGinn, Luiz; Ramsey, Bailey, Watkins
Subs: Olsen, Tielemans, Digne, Torres, Diaby, Zaniolo, Rogers, Kesler-Hayden, Iroegbunam
Man Utd team news
Team to play Aston Villa: Onana, Dalot, Maguire, Varane, Shaw, Casemiro, Mainoo, Fernandes, Garnacho, Hojlund, Rashford
Subs: Bayindir, Evans, Lindelof, Amad, Amrabat, Eriksen, Forson, McTominay, Antony
