Wesley Fofana goes straight into the Chelsea side after his £70m arrival from Leicester City, as Thomas Tuchel makes five changes to the side beaten at Southampton.
Reece James replaces Cesar Azpilicueta and Conor Gallagher returns from suspension, while Mateo Kovacic and Christian Pulisic also start.
Jorginho, Mason Mount, Hakim Ziyech and Kai Havertz are the others to drop out.
Chelsea XI: Mendy, James, Silva, Koulibaly Fofana, Cucurella, Gallagher, Loftus-Cheek, Kovacic, Pulisic, Sterling.
Lucas Paqueta makes his first start for West Ham, who make two changes following their draw with Tottenham. Former Chelsea left-back Emerson is the other player to come in, replacing Aaron Cresswell.
West Ham XI: Fabianski, Coufal, Zouma, Kehrer, Emerson, Ricr, Paqueta, Soucek, Fornals, Bowen, Antonio
