Marco Silva reverts to a more familiar starting lineup from the one that started the FA Cup third round win over Rotherham last week, as Marek Rodak, Kenny Tete, Sasa Lukic, Harry Wilson and Rodrigo Muniz drop to the bench.
In come Bernd Leno, Antonee Robinson, Joao Palhinha, Willian and Raul Jimenez.
Liverpool boss Jurgen Klopp also rings the changes, returning to a more familiar team.
Joe Gomez, Harvey Elliott, Alexis Mac Allister, Curtis Jones Ibrahima Konate and Luis Diaz keep their places following the FA Cup win over Arsenal.
Caoimhin Kelleher starts his 10th game of the season in goal, while Virgil van Dijk returns. Diogo Jota and Ryan Gravenberch are also in from the off, while Conor Bradley replaces Trent Alexander-Arnold at right-back.
Fulham team news
Starting XI: Leno, Castagne, Tosin, Diop, Robinson, Palhinha, De Cordova-Reid, Andreas, Willian, Jimenez.
Subs: Rodak, Tete, Ream, Lukic, Francois, Cairney, Wilson, Muniz, Vinicius.
Liverpool team news
Starting XI: Kelleher, Gomez, Van Dijk, Konate, Diaz, Mac Allister, Jones, Elliott, Jota, Gravenberch, Bradley.
Subs: Alisson, Nunez, Gakpo, Clark, Gordon, McConnell, Beck, Quansah, Nyoni.
