Amad Diallo is given his first Premier League start of the season for Manchester United.
The forward comes in along with Sofyan Amrabat and Scott McTominay, who returns from injury.
There is no place in the squad for Bruno Fernandes, who returned to training this week after missing the 4-0 defeat by Crystal Palace. Mason Mount is ruled out through injury.
Man Utd XI: Onana, Dalot, Casemiro, Evans, Wan-Bissaka, Mainoo, Amrabat, Diallo, McTominay, Garnacho, Hojlund.
Subs: Bayindir, Eriksen, Antony, Kambwala, Forson, Collyer, Amass, Ogunneye, Wheatley.
Arsenal, meanwhile, name the same starting XI from the 3-0 win against Bournemouth last-time out.
Takehiro Tomiyasu and Bukayo Saka were fitness doubts in midweek but have recovered to take their place in the side.
Arsenal XI: Raya, White, Saliba, Gabriel, Tomiyasu, Odegaard, Partey, Rice, Saka, Havertz, Trossard.
Subs: Ramsdale, Gabriel Jesus, Smith Rowe, Martinelli, Nketiah, Kiwior, Jorginho, Vieira, Zinchenko.
