Erik ten Hag makes three changes from the Manchester United side who were beaten 3-1 by Arsenal before the international break.
Aaron Wan-Bissaka and Anthony Martial drop to the bench, while winger Antony has taken a leave of absence following assault allegations made against him.
They are replaced by Sergio Reguilon, Rasmus Hojlund and Scott McTominay.
Manchester United XI: Onana; Dalot, Lindelof, Martinez, Reguilon; Casemiro, McTominay; Fernandes, Eriksen, Rashford; Hojlund.
Subs: Bayindir, Maguire, Martial, Garnacho, Pellistri, Wan-Bissaka, Evans, Gore, Mejbri.
Roberto de Zerbi names six different players from the Brighton starting lineup who beat Newcastle United last time out.
Striker Evan Ferguson, who registered a hat-trick, can only make the bench after picking up an injury on international duty.
Pervis Estupinan and Solly March are absent from the squad, while Bart Verbruggen, Billy Gilmour and Joao Pedro are benched.
They are replaced by Jason Steele, Tariq Lamptey, Mahmoud Dahoud, Adam Lallana, Danny Welbeck and Simon Adingra.
Deadline day signing Ansu Fati is among the substitutes.
Brighton XI: Steele; Lamptey, Van Hecke, Dunk, Veltman; Gross, Dahoud; Adingra, Lallana, Mitoma; Welbeck.
Subs: Verbruggen, Julio, Webster, Milner, Pedro, Gilmour, Baleba, Ferguson, Fati.
