Seven of the players to start against City on Sunday are out of the team, with Bruno Fernandes and Marcus Rashford the headline names on the bench.
Casemiro does return after missing the last few games with injury. In midfield, he plays alongside Mason Mount and Hannibal Mejbri.
Just one change at the back as Sergio Reguilon replaces Jonny Evans, making his first start since recovering from injury.
The front three has been completely changed with Alejandro Garnacho, Antony and Anthony Martial starting up top.
Newcastle team news
Newcastle: Dubravka; Livramento, Krafth, Dummet, Targett; Hall, Longstaff, Willock; Ritchie, Joelinton, Gordon.
Subs: Karius, Trippier, Lascelles, Wilson, Almiorn, Burn, Bruno G, Diallo, Parkinson.
Man Utd team news
Man Utd: Onana; Dalot, Maguire, Lindelof, Reguilon; Casemiro, Hannibal, Mount; Antony, Martial, Garnacho.
Subs: Bayindir, Evans, Wan-Bissaka, Amrabat, Fernandes, Eriksen, McTominay, Hojlund, Rashford.
