Edin Terzic makes two changes to his Dortmund side that saw off Werder Bremen on Friday, but both are ones he would have liked to avoid.
Star man Julian Brandt, who scored the winner in that game before he was taken off, misses out with what the club has labelled a “muscular problem” suffered during the match.
That change was not expected, unlike the missing Julian Ryerson who did not travel to England after coming down with illness.
Former Man Utd loanee Marcel Sabitzer and Ramy Bensebaini come in for the absent pair.
The two changes to Newcastle’s starting line-up are largely expected, with Alexander Isak leading the line ahead of Callum Wilson, as he did against PSG in the Magpies’ last Champions League game.
Miguel Almiron also returns in place of Jacob Murphy, after being rested like Isak against Crystal Palace at the weekend.
Sandro Tonali is again on the bench amid his ongoing situation with the Italian football authorities over alleged betting offences.
Borussia Dortmund team news – Brandt misses out with injury
Team to play Newcastle: Kobel; Wolf, Hummels, Schlotterbeck, Bensebaini; Can, Nmecha, Sabitzer; Reus, Fullkrug, Malen.
Subs: Meyer, Lotka, Ozcan, Reyna, Haller, Moukoko, Sule, Adeyemi, Blank, Bynoe-Gittens.
Newcastle team news – Isak and Almiron start | Tonali on bench
Team to play Borussia Dortmund: Pope; Trippier, Lascelles, Schar, Burn; Longstaff, Guimaraes, Joelinton; Almiron, Isak, Gordon.
Subs: Dubravka, Karius, Dummett, Tonali, Wilson, Targett, Hall, Livramento, Murphy, Willock.
