Napoli, who are currently atop the Serie A standings, have yet to suffer a league defeat this year, and they will be aiming to keep that streak alive by defeating Empoli.
The defending champions, AC Milan, are currently in second place but cannot afford to lose any ground when they travel to Cremonese.
In other matches, Juventus will hope to maintain their recent upswing against bottom-placed Verona, while Inter Milan can recover from Sunday’s Old Lady loss to Bologna.
Lazio gained ground on Monza last time out with a derby victory, and they hope to build on that momentum this time around.
Napoli’s chances of winning the Scudetto were greatly enhanced by their victory over Atalanta last Saturday.
The victory increased their winning streak to nine straight Serie A contests and gave them a six-point lead at the top of the standings.
In fact, Luciano Spalletti’s team has only suffered one defeat across all competitions this season, a 2-0 loss to Liverpool on the road in the Champions League after they had already qualified by winning each of their first five group games.
When Empoli, who has just three victories and is tied for the second-lowest goal scorer in the league with 10 goals, visits Naples, the Partenopei will undoubtedly hope to extend that streak to 10 straight league victories.
Game of the week:
Napoli vs Empoli (Tuesday, 5.30pm)
Cremonese vs AC Milan (Tuesday, 7.45pm)
Verona vs Juventus (Thursday, 5.30pm)
Inter Milan vs Bologna (Wednesday, 7.45pm)
Lazio vs Monza (Thursday, 7.45pm)
Spezia vs Udinese (Tuesday, 5.30pm)
Lecce vs Atalanta (Wednesday, 5.30pm)
Sassuolo vs Roma (Wednesday, 5.30pm)
Fiorentina vs Salernitana (Wednesday, 7.45pm)
Torino vs Sampdoria (Wednesday, 7.45pm)
