Ange Postecoglou has been forced into four changes following the chaotic 4-1 defeat against Chelsea on Monday.
Cristian Romero and Destiny Udogie begin their suspensions for their red cards against the Blues, with Eric Dier and Ben Davies taking their places.
Micky van de Ven and James Maddison sustained long-term injuries in the damaging defeat, meaning Emerson Royal will take up an unfamiliar role at centre-back, while Pierre-Emile Hojbjerg comes into a midfield three.
Gary O’Neil has made two changes to the Wolves side that lost at Sheffield United last weekend.
Tommy Doyle and Sasa Kalajdzic drop to the bench, with Jean-Ricner Bellegarde and Joao Gomes coming into the side to face Tottenham.
Hugo Bueno returns to the bench after injury but Pedro Neto remains out.
Tottenham team news
Team to play Wolves: Vicario; Porro, Royal, Dier, Davies; Sarr, Hojbjerg, Bissouma; Kulusevski, Son, Johnson.
Subs: Forster, Skipp, Gil, Lo Celso, Bentancur, Phillips, Veliz, Donley, Dorrington.
Wolves team news
Team to play Tottenham: Sa; Semedo, Dawson, Kilman, Toti; Bellegarde, Lemina, Gomes, Ait-Nouri; Hwang, Cunha.
Subs: Bentley, Doherty, Traore, Silva, Bueno, Kalajdzic, Jonny, Doyle, Sarabia.
